calanka

Nickel-catalyzed deaminative Sonogashira isku-xidhka cusbada alkylpyridinium oo uu awooday NN2 pincer ligand

Alkynes waxay si ballaaran ugu jiraan alaabada dabiiciga ah, molecules bayooloji firfircoon iyo walxaha waxtarka leh ee dabiiciga ah.Isla mar ahaantaana, waxay sidoo kale yihiin dhexdhexaadiye muhiim u ah isku-dhafka dabiiciga ah waxayna mari karaan falcelin kiimiko oo badan.Sidaa darteed, horumarinta hababka dhismaha alkynes fudud oo hufan ayaa si gaar ah degdeg u ah oo loo baahan yahay.In kasta oo falcelinta Sonogashira ee ay kacday biraha kala-guurka ay tahay mid ka mid ah siyaabaha ugu waxtarka badan uguna habboon ee lagu soo saari karo aryl ama alkynes beddelka alkynes, falcelinta isku-xidhka ee ku lug leh falcelinta alkyl electrophiles ee aan firfircoonayn ayaa sabab u ah falcelinta dhinaca sida baabi'inta bH.Weli waxaa ka buuxa caqabado iyo cilmi-baaris yar, oo badiyaa ku xaddidan deegaanka aan saaxiibtinimo lahayn iyo alkanes-ka qaaliga ah ee qaaliga ah.Sidaa darteed, sahaminta iyo horumarinta falcelinta Sonogashira ee reagents cusub, raqiis ah oo si fudud loo heli karo waxay noqon doontaa mid muhiimad weyn u leh labadaba shaybaarka iyo codsiyada warshadaha.Kooxdu waxay si xariif ah u qaabeeyeen oo ay u horumariyeen nooc cusub oo si fudud loo heli karo oo deggan amide-nooca NN2 pincer ligand, kaas oo markii ugu horeysay xaqiiqsaday xulashada hufan iyo xulashada sare ee alkylamine-ka iyo alkynes terminal oo leh ilo kala duwan oo nikkel catalytic ah, raqiis ah oo sahlan helaan.Dareen-celinta isku-dhafka ah ayaa si guul leh loogu dabaqay deamination-da dambe iyo wax-ka-beddelka alkynylation ee alaabta dabiiciga ah ee adag iyo molecules daroogada, taas oo muujinaysa waxqabadka falcelinta wanaagsan iyo iswaafajinta kooxda shaqada, oo siisa wax cusub oo loogu talagalay isku-dhafka muhiimka ah ee alkynes-la beddelay.Iyo habab wax ku ool ah.


Waqtiga boostada: Nov-22-2021