Alkynes-ka ayaa si weyn u soo bandhigaya alaabada dabiiciga ah, bayooloji ahaan-bayoolaji ahaan firfircoon iyo ashyaa'da firfircoon ee dabiiciga ah. Isla mar ahaantaana, iyaguna waa muhiim isbarbardhigaya isku xirnaan dabiici ah waxayna mari karaan falcelin isbadal oo kiimiko ah oo kiimikada ah. Sidaa darteed, horumarinta hababka dhismaha ee sahlan oo hufan ee hababka dhismaha ee sahlan ayaa gaar ahaan deg deg ah oo loo baahan yahay. In kasta oo falcelinnada Sonogashira ay ka soo saartay biraha ku-meel-gaarka ah waa mid ka mid ah qaababka ugu wax ku oolka badan uguna habboon ee lagu beddeli karo arkynes, falcelin isku-darka ah ee ku lug leh elektaroonigyada alkyl ee aan firfircoonayn waxaa sabab u ah fal-celinta dhinaca ah ee BH. Wali ka buuxa caqabado iyo daraasad ka yar, badiyaa waxay ku koobnaataa bey'ada bay'ada aan caadiga ahayn oo aan caadi ahayn. Sidaa darteed, sahaminta iyo horumarinta Sonogashira ee dib-u-soo-celinta dadka cusub ee cusub, kuwa rakhiis ah oo si sahlan loo heli karo ayaa ahmiyad weyn ka yeelan doonaan labadaba sconthesis-ka sheybaarka iyo codsiyada warshadaha. Kooxda si xariif ah u qaabeeyey oo ay horumarisay mid cusub, oo si sahlan loo heli karo iyo kuwa xasilloon ee NN2, taas oo markii ugu horreysay ay ogaadeen in si hufan oo xulasho ah oo ka mid ah ilo badan oo ilo ah oo kaladuwan, raqiis ah oo fudud hel. Falcelinta isku-darka-iskutallaabta ayaa si guul leh loogu dabaqaysaa wax ka beddelka dib-u-dejinta iyo alulolation-ka dababka ah ee alaabada dabiiciga ah ee adag iyo molocules daroogada, oo ay muujineyso waxqabadka wanaagsan ee falcelinta, waxayna siisaa sheeko ku saabsan isku-darka alkyles muhiim ah. Iyo habab ficil ah.
Waqtiga Post: Nov-22-2021